Abstract Treatment-resistant depression affects up to 20% of individuals suffering from major
depressive disorder (MDD). The medications currently available to treat depression …

Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …

Stroke is the second leading cause of death globally and the major cause of long-term
disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of …

Anhedonia is a common, persistent, and disabling condition. However, available
therapeutics primarily focus on the reduction of depressive and negative symptoms rather …

Background Racemic ketamine consists of two enantiomers, namely (R)-ketamine and (S)-
ketamine, with distinguishable pharmacological properties. Both enantiomers have been …

Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could
be associated with the pathophysiology of depression. This study investigated the markers …

Approximately one-third of individuals with major depressive disorder are resistant to
conventional antidepressants (ie, monoamine-based therapies), and, even among …

While neurotransmitter dysfunction represents a key component in mental illnesses, there is
now a wide agreement for a central pathophysiological hub that includes hormones …

Objectives. Active inflammatory responses play an important role in the pathogenesis of
depression. We hypothesized that the rapid antidepressant effect of ketamine is associated …

Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as
a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic …