In the last two or three decades the emphasis on and applications of green chemical
principles, introduced some significant advances in organic synthesis, such as combinatorial …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Following the discovery of the human kinome, protein kinases have become the second
most important group of drug targets as they can be modulated by small ligand molecules …

Introduction: The conventional term 'casein kinase'(CK) denotes three classes of kinases–
CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) …

The CuSO4 catalyzed three-component reaction of indole-2-acetate, aromatic aldehydes
and 3-methyleneoxindoles in toluene at 130° C afforded polysubstituted spiro [carbazole-3 …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Protein kinases are central components of signal transduction cascades often dysregulated
in cancer, and they represent some of the most promising drug targets. However, the target …

Within the last decade, 40 crystal structures corresponding to protein kinase CK2 (former
name 'casein kinase 2'), to its catalytic subunit CK2α and to its regulatory subunit CK2β were …

Recently we reported the discovery of a potent and selective CK2α inhibitor CAM4066. This
compound inhibits CK2 activity by exploiting a pocket located outside the ATP binding site …