Longstanding hypertension ultimately leads to heart failure (HF), and, as a consequence
most patients with HF have a history of hypertension. Conversely, absence of hypertension …

Importance Patients with heart failure with preserved ejection fraction (HFpEF) with a
pacemaker may benefit from a higher, more physiologic backup heart rate than the nominal …

Since noninvasive central blood pressure (BP) measuring devices are readily available,
central BP has gained growing attention regarding its clinical application in the management …

An elevated resting heart rate has been unequivocally linked to adverse cardiovascular
events. Conversely, a physiologically low heart rate may confer longevity benefits. Moreover …

Ivabradine is a unique agent that is distinct from beta-blockers and calcium channel blockers
as it reduces heart rate without affecting myocardial contractility or vascular tone. Ivabradine …

Background Ivabradine has potent actions in reducing heart rate and improving clinical
outcomes of chronic heart failure with reduced ejection fraction (HFrEF). At present, only the …

Heart failure (HF) is a major problem of public health. More than 23 million patients
worldwide are affected by heart failure. Despite incidence and prevalence of heart failure …

Aims Ivabradine and sacubitril/valsartan are second‐line therapies for patients with heart
failure and reduced ejection fraction (HFrEF) based on guideline recommendations. We …

Epidemiological studies have demonstrated that high resting heart rates are associated with
increased mortality. Clinical studies in patients with heart failure and reduced ejection …

Arterial wave reflection has been shown to have a significant dependence on heart rate
(HR). However, the underlying mechanisms inherent in the HR dependency of wave …