This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

Cyclotides are plant-derived mini proteins. They are genetically encoded as precursor
proteins that become post-translationally modified to yield circular cystine-knotted …

Cyclotides are a unique class of ribosomally synthesized cysteine‐rich miniproteins
characterized by a head‐to‐tail cyclized backbone and three conserved disulfide‐bonds in a …

Bioactive peptides are a highly abundant and diverse group of molecules that exhibit a wide
range of structural and functional variation. Despite their immense therapeutic potential …

The emergence and re-emergence of viral epidemics and the risks of antiviral drug
resistance are a serious threat to global public health. New options to supplement or replace …

Greater levels of insect resistance and constraints on the use of current pesticides have
recently led to increased crop losses in agricultural production. Further, the health and …

Owing to their exceptional stability and favourable pharmacokinetic properties, plant-derived
cyclic peptides have recently attracted significant attention in the field of peptide-based drug …

Host defence peptides (HDPs) are antimicrobial agents produced by organisms across the
prokaryotic and eukaryotic kingdoms. Many prokaryotes produce HDPs, which utilise lipid …

Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous
system that causes chronic inflammation. Cyclotides are small plant proteins with a wide …