Liver cancer represents a major health problem worldwide with growing incidence and high
mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely …

The mechanical signals within the extracellular matrix (ECM) regulate cell growth,
proliferation and differentiation, and integrins function as the hub between the ECM and …

Previous data indicate that C3G (RapGEF1) main isoform is highly expressed in liver
progenitor cells (or oval cells) compared to adult mature hepatocytes, suggesting it may play …

Abstract C3G is a GEF (guanine nucleotide exchange factor) for Rap GTPases, among
which the isoform Rap1b is an essential protein in platelet biology. Using transgenic mouse …

In this study, we compared the antioxidant activities of cyanidin-3-O-glucoside (C3G) and
C3G liposomes. We also compared the anticancer activities of C3G and C3G liposomes in …

Rationale: Metabolic syndrome (MetS) is a cluster of interrelated risk factors for
cardiovascular diseases and atherosclerosis. Circulating levels of large extracellular …

Rap proteins regulate liver physiopathology. For example, Rap2B promotes
hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1 …

Glioblastoma (GBM) is the most aggressive tumor from the central nervous system (CNS).
The current lack of efficient therapies makes essential to find new treatment strategies. C3G …

Previous observations indicated that C3G (RAPGEF1) promotes α-granule release,
evidenced by the increase in P-selectin exposure on the platelet surface following its …

Objectives Rheumatoid arthritis (RA) is an autoimmune polyarthritis, in which fibroblast-like
synoviocytes (FLS) play a key role in cartilage and bone destruction through tumour-like …