Natural selection acts on the phenotype. Therefore, many mistakenly expect to observe its
signatures only in the organism, while overlooking its impact on tissues, cells and …

In plants, mitochondrial respiration supplies energy for biosynthesis, and its equilibrium with
photosynthesis determines the accumulation rate of plant biomass. Though the …

The maternally inherited mitochondrial DNA (mtDNA) is located inside every mitochondrion,
in variable number of copies, and it contains 37 crucial genes for cellular bioenergetics. This …

Placental insufficiency is implicated in spontaneous preterm birth (SPTB) associated with
intrauterine inflammation. We hypothesized that intrauterine inflammation leads to deficits in …

The fine control of birth timing is important to human survival and evolution. A key challenge
in studying the mechanisms underlying the regulation of human birth timing is that human …

Oocyte quality is one of the most important factors involving in female reproduction. The
number of compromised oocytes will increase with maternal age, while mitochondrial …

Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited
genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a …

Preterm birth (PTB) is a major cause of neonatal mortality and health complications in
infants. Elucidation of its genetic underpinnings can lead to improved understanding of the …

Background We examined over a million California birth records for 2010 through 2021 to
investigate whether disparities in preterm birth (PTB) by nativity and race support the widely …

Preterm birth (PTB), or birth that occurs earlier than 37 weeks of gestational age, is a major
contributor to infant mortality and neonatal hospitalization. Mutations in the mitochondrial …