Role of cytochrome P450s in the generation and metabolism of reactive oxygen species

A Veith, B Moorthy - Current opinion in toxicology, 2018 - Elsevier
The cytochrome P450 (CYP) enzymes are a diverse group of heme monooxygenases that,
through the course of their reaction cycle, can contribute to cellular reactive oxygen species …

Mechanisms of catalytic reduction of CO 2 with heme and nonheme metal complexes

S Fukuzumi, YM Lee, HS Ahn, W Nam - Chemical science, 2018 - pubs.rsc.org
The catalytic conversion of CO2 into valuable chemicals and fuels has attracted increasing
attention, providing a promising route for mitigating the greenhouse effect of CO2 and also …

Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms

M Szaleniec, AM Wojtkiewicz, R Bernhardt… - Applied Microbiology …, 2018 - Springer
The steroid superfamily includes a wide range of compounds that are essential for living
organisms of the animal and plant kingdoms. Structural modifications of steroids highly affect …

Recent insights into pesticide resistance mechanisms in Plutella xylostella and possible management strategies

M Shehzad, I Bodlah, JA Siddiqui, MA Bodlah… - … Science and Pollution …, 2023 - Springer
Insects are incredibly successful and diverse organisms, but they also pose a significant
threat to agricultural crops, causing potential losses of up to US 470billion.Amongthesepests …

Melatonin activation by human cytochrome P450 enzymes: A comparison between different isozymes

T Mokkawes, T De Visser, Y Cao, SP De Visser - Molecules, 2023 - mdpi.com
Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis
and the degradation of the hormone melatonin. Melatonin plays a key role in circadian …

Selectivity-Determining Steps in O2 Reduction Catalyzed by Iron(tetramesitylporphyrin)

AC Brezny, SI Johnson, S Raugei… - Journal of the American …, 2020 - ACS Publications
The oxygen reduction reaction (ORR) is the cathode reaction in fuel cells and its selectivity
for water over hydrogen peroxide production is important for these technologies. Iron …

Cytochrome P450 monooxygenase systems: Diversity and plasticity for adaptive stress response

IM Mokhosoev, DV Astakhov, AA Terentiev… - Progress in Biophysics …, 2024 - Elsevier
Superfamily of cytochromes P450 (CYPs) is composed of heme-thiolate-containing
monooxygenase enzymes, which play crucial roles in the biosynthesis, bioactivation, and …

Melatonin activation by cytochrome P450 isozymes: how does CYP1A2 compare to CYP1A1?

T Mokkawes, SP de Visser - International Journal of Molecular Sciences, 2023 - mdpi.com
Cytochrome P450 enzymes are versatile enzymes found in most biosystems that catalyze
mono-oxygenation reactions as a means of biosynthesis and biodegradation steps. In the …

Modulating the coupling efficiency of P450 BM3 by controlling water diffusion through access tunnel engineering

S Meng, Y Ji, L Liu, MD Davari… - …, 2022 - Wiley Online Library
Cytochromes P450 have gained much interest for their broad substrate scope in the
catalysis of oxidation reactions for pharmaceuticals, plastics, and hormones. However …

Dynamic Ir (III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4

M Denison, JJ Ahrens, MN Dunbar… - Inorganic …, 2023 - ACS Publications
Probing the activity of cytochrome P450 3A4 (CYP3A4) is critical for monitoring the
metabolism of pharmaceuticals and identifying drug–drug interactions. A library of Ir (III) …