Interfering RNA molecules
K Giese, J Kaufmann, A Klippel-Giese - US Patent 7,452,987, 2008 - Google Patents
The present invention is related to a ribonucleic acid com prising a double stranded
structure whereby the double Stranded structure comprises a first strand and a second …
structure whereby the double Stranded structure comprises a first strand and a second …
Methods for treating hypercholesterolemia
SM Freier, RM Crooke, MJ Graham… - US Patent …, 2012 - Google Patents
2009-08-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Modified RNAi polynucleotides and uses thereof
The invention relates to improved RNAi constructs and uses thereof. The construct has a
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …
Modulators of pharmacological agents
BA Sullenger, CP Rusconi - US Patent 7,300,922, 2007 - Google Patents
The biological activity of nucleic acid ligand is regulated (ie enhanced or inhibited) in vivo to
produce a desired biological e?'ect. This is accomplished through the admin istration of a …
produce a desired biological e?'ect. This is accomplished through the admin istration of a …
Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds
The present invention provides, inter alia, methods of Select ing a single-Stranded
oligomeric compounds for inhibiting RNA expression, methods of generating double …
oligomeric compounds for inhibiting RNA expression, methods of generating double …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2018 - Google Patents
2013-06-19 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …