Genetic architecture of schizophrenia: a review of major advancements
SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …
technological advancements have led to a substantial increase in knowledge of the genetic …
[HTML][HTML] Gene-environment interactions in schizophrenia: a literature review
MH Wahbeh, D Avramopoulos - Genes, 2021 - mdpi.com
Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …
subject of extensive research. Despite the high heritability, it is well recognized that non …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
[PDF][PDF] Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
Genome-wide association studies have successfully discovered thousands of common
variants associated with human diseases and traits, but the landscape of rare variations in …
variants associated with human diseases and traits, but the landscape of rare variations in …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Indonesia Schizophrenia Consortium… - Nature, 2022 - research.vu.nl
Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
[PDF][PDF] Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Human genome variation contributes to diversity in neurodevelopmental outcomes and
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
Autism spectrum disorder genetics and the search for pathological mechanisms
Recent progress in the identification of genes and genomic regions contributing to autism
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
Toward recovery in schizophrenia: Current concepts, findings, and future research directions
T Onitsuka, Y Hirano, T Nakazawa… - Psychiatry and …, 2022 - Wiley Online Library
Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …
progressive deterioration. However, recent studies have revealed that early effective …