The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

A healthy nutritional state is required for all aspects of reproduction and is signaled by the
adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little …

Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Obesity is currently the most extended metabolic disturbance worldwide favoring the
development of cardiometabolic alterations such as type 2 diabetes, hypertension, and …

Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a
common signaling pathway used to transduce signals from the extracellular to the …

Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …