Neuroimaging biomarkers in schizophrenia
NV Kraguljac, WM McDonald… - American Journal of …, 2021 - Am Psychiatric Assoc
Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies
Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
[HTML][HTML] Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Association of ketamine with psychiatric symptoms and implications for its therapeutic use and for understanding schizophrenia: a systematic review and meta …
Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
A single ketamine infusion combined with mindfulness-based behavioral modification to treat cocaine dependence: a randomized clinical trial
E Dakwar, EV Nunes, CL Hart… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Research has suggested that subanesthetic doses of ketamine may work to
improve cocaine-related vulnerabilities and facilitate efforts at behavioral modification. The …
improve cocaine-related vulnerabilities and facilitate efforts at behavioral modification. The …
A single ketamine infusion combined with motivational enhancement therapy for alcohol use disorder: a randomized midazolam-controlled pilot trial
Objective: Pharmacotherapy and behavioral treatments for alcohol use disorder are limited
in their effectiveness, and new treatments with innovative mechanisms would be valuable. In …
in their effectiveness, and new treatments with innovative mechanisms would be valuable. In …
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
[HTML][HTML] The anterior cingulate cortex as a key locus of ketamine's antidepressant action
The subdivisions of the anterior cingulate cortex (ACC)–including subgenual, perigenual
and dorsal zones–are implicated in the etiology, pathogenesis and treatment of major …
and dorsal zones–are implicated in the etiology, pathogenesis and treatment of major …