Use of machine learning approaches for novel drug discovery
abstract Introduction: The use of computational tools in the early stages of drug development
has increased in recent decades. Machine learning (ML) approaches have been of special …
has increased in recent decades. Machine learning (ML) approaches have been of special …
Three-dimensional protein structure prediction: Methods and computational strategies
A long standing problem in structural bioinformatics is to determine the three-dimensional (3-
D) structure of a protein when only a sequence of amino acid residues is given. Many …
D) structure of a protein when only a sequence of amino acid residues is given. Many …
The PSIPRED protein analysis workbench: 20 years on
DWA Buchan, DT Jones - Nucleic acids research, 2019 - academic.oup.com
The PSIPRED Workbench is a web server offering a range of predictive methods to the
bioscience community for 20 years. Here, we present the work we have completed to update …
bioscience community for 20 years. Here, we present the work we have completed to update …
Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein
Q Ye, AMV West, S Silletti, KD Corbett - Protein Science, 2020 - Wiley Online Library
The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …
century. To properly address this crisis with both robust testing and novel treatments, we …
Integrative structure and functional anatomy of a nuclear pore complex
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
Structural basis of assembly of the human T cell receptor–CD3 complex
The αβ T cell receptor (TCR), in association with the CD3γε–CD3δε–CD3ζζ signalling
hexamer, is the primary determinant of T cell development and activation, and of immune …
hexamer, is the primary determinant of T cell development and activation, and of immune …
Structure of paused transcription complex Pol II–DSIF–NELF
Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …
[HTML][HTML] Cryo-EM structure of the open human ether-à-go-go-related K+ channel hERG
W Wang, R MacKinnon - Cell, 2017 - cell.com
The human ether-à-go-go-related potassium channel (hERG, Kv11. 1) is a voltage-
dependent channel known for its role in repolarizing the cardiac action potential. hERG …
dependent channel known for its role in repolarizing the cardiac action potential. hERG …
The architecture of respiratory supercomplexes
Mitochondrial electron transport chain complexes are organized into supercomplexes
responsible for carrying out cellular respiration. Here we present three architectures of …
responsible for carrying out cellular respiration. Here we present three architectures of …