Rates of alcohol use disorder (AUD) have increased in women by 84% over the past ten
years relative to a 35% increase in men. This substantive increase in female drinking is …

Research conducted over the past several decades has revolutionized our understanding of
the role of the immune system in neural and psychological development and function across …

Accumulating evidence has indicated that activation of microglia and neuroinflammation
reaction play a prominent role in Alzheimer's disease (AD). Inhibition of toll-like receptor 4 …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …

Several studies have described a dose-dependent effect of alcohol on human health with
light to moderate drinkers having a lower risk of all-cause mortality than abstainers, while …

Parkinson's disease is characterized by a progressive degeneration of substantia nigra (SN)
dopaminergic neurons with age. We previously found that a single systemic …

Microglia are a heterogenous group of monocyte-derived cells serving multiple roles within
the brain, many of which are associated with immune and macrophage like properties …

Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

Excessive alcohol intake, a defining characteristic of an alcohol use disorder (AUD), results
in neurodegeneration in the hippocampus and entorhinal cortex that has been linked to a …