Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)

AR Bourgonje, AE Abdulle, W Timens… - The Journal of …, 2020 - Wiley Online Library
Abstract Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional
host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19

D Zipeto, JF Palmeira, GA Argañaraz… - Frontiers in …, 2020 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …

[HTML][HTML] Neuropathology of COVID-19 (neuro-COVID): clinicopathological update

JJ Lou, M Movassaghi, D Gordy, MG Olson… - Free …, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health
crisis in the early 21 st century. Its causative agent, Severe Acute Respiratory Syndrome …

Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study

W Hu, X Lv, C Li, Y Xu, Y Qi, Z Zhang, M Li… - Internal and Emergency …, 2021 - Springer
Background The worldwide spread of SARS-CoV-2 has infected millions of people leading
to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common …

[HTML][HTML] ACE and ACE2 in kidney disease

S Mizuiri, Y Ohashi - World journal of nephrology, 2015 - ncbi.nlm.nih.gov
Renin angiotensin system (RAS) activation has a significant influence on renal disease
progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang …

ACE/ACE2 ratio: a key also in 2019 coronavirus disease (Covid-19)?

P Pagliaro, C Penna - Frontiers in medicine, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is an aminopeptidase that converts Angiotensin
(Ang) II into Ang (1-7). Coronavirus uses ACE2 as a cellular receptor to invade target cells …

Epithelial and Endothelial Expressions of ACE2: SARS-CoV-2 Entry Routes.

C Guney, F Akar - Journal of pharmacy & pharmaceutical sciences …, 2021 - avesis.gazi.edu.tr
Angiotensin converting enzyme 2 (ACE2) is a main receptor for SARS-CoV-2 entry to the
host cell. ACE2 is one of the key enzymes in renin-angiotensin system and plays a vital role …

An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019 …

CA Devaux, L Camoin-Jau - Frontiers in microbiology, 2022 - frontiersin.org
It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …