The tumor microenvironment innately modulates cancer progression
DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
Macrophage polarization in physiological and pathological pregnancy
Y Yao, XH Xu, L Jin - Frontiers in immunology, 2019 - frontiersin.org
The immunology of pregnancy is complex and poorly defined. During the complex process
of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in …
of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in …
OMIP‐069: forty‐color full spectrum flow cytometry panel for deep immunophenotyping of major cell subsets in human peripheral blood
LM Park, J Lannigan, MC Jaimes - Cytometry Part A, 2020 - Wiley Online Library
PURPOSE AND APPROPRIATE SAMPLE TYPES This 40‐color flow cytometry‐based panel
was developed for in‐depth immunophenotyping of the major cell subsets present in human …
was developed for in‐depth immunophenotyping of the major cell subsets present in human …
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Motivation The composition and density of immune cells in the tumor microenvironment
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
New treatment addressing the pathogenesis of psoriasis
M Tokuyama, T Mabuchi - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL) 23/IL17
axis plays an important role in the development of psoriasis. The effectiveness of biologic …
axis plays an important role in the development of psoriasis. The effectiveness of biologic …
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …
development over recent decades. However, this field is currently in a state of flux toward …
Spatiotemporal immune zonation of the human kidney
Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …
Dendritic cell-based immunotherapy
RL Sabado, S Balan, N Bhardwaj - Cell research, 2017 - nature.com
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in …
harnessing the potential of a patient's own immune system to eliminate tumor cells in …
Single-cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment
Purpose: The tumor microenvironment (TME) consists of a heterogenous cellular milieu that
can influence cancer cell behavior. Its characteristics have an impact on treatments such as …
can influence cancer cell behavior. Its characteristics have an impact on treatments such as …
Spatial density and distribution of tumor-associated macrophages predict survival in non–small cell lung carcinoma
The respective antitumoral and protumoral roles of M1 and M2 tumor-associated
macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer …
macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer …