The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …
analytic tools and access to depositories of curated data relevant to immune reactions and …
[HTML][HTML] An overview of bioinformatics tools for epitope prediction: implications on vaccine development
RE Soria-Guerra, R Nieto-Gomez… - Journal of biomedical …, 2015 - Elsevier
Exploitation of recombinant DNA and sequencing technologies has led to a new concept in
vaccination in which isolated epitopes, capable of stimulating a specific immune response …
vaccination in which isolated epitopes, capable of stimulating a specific immune response …
Evolution of neoantigen landscape during immune checkpoint blockade in non–small cell lung cancer
Immune checkpoint inhibitors have shown significant therapeutic responses against tumors
containing increased mutation-associated neoantigen load. We have examined the evolving …
containing increased mutation-associated neoantigen load. We have examined the evolving …
PD-1 blockade in tumors with mismatch-repair deficiency
Background Somatic mutations have the potential to encode “non-self” immunogenic
antigens. We hypothesized that tumors with a large number of somatic mutations due to …
antigens. We hypothesized that tumors with a large number of somatic mutations due to …
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …
Gapped sequence alignment using artificial neural networks: application to the MHC class I system
M Andreatta, M Nielsen - Bioinformatics, 2016 - academic.oup.com
Motivation: Many biological processes are guided by receptor interactions with linear
ligands of variable length. One such receptor is the MHC class I molecule. The length …
ligands of variable length. One such receptor is the MHC class I molecule. The length …
Design of a multiepitope‐based peptide vaccine against the e protein of human COVID‐19: an immunoinformatics approach
MI Abdelmageed, AH Abdelmoneim… - BioMed research …, 2020 - Wiley Online Library
Background. A new endemic disease has spread across Wuhan City, China, in December
2019. Within few weeks, the World Health Organization (WHO) announced a novel …
2019. Within few weeks, the World Health Organization (WHO) announced a novel …
[HTML][HTML] Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient
A Jiménez-Sánchez, D Memon, S Pourpe… - Cell, 2017 - cell.com
We present an exceptional case of a patient with high-grade serous ovarian cancer, treated
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …
A large fraction of HLA class I ligands are proteasome-generated spliced peptides
The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class
I molecules that elicit CD8+ T cell responses. Reports of proteasome-generated spliced …
I molecules that elicit CD8+ T cell responses. Reports of proteasome-generated spliced …
NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets
M Nielsen, M Andreatta - Genome medicine, 2016 - Springer
Background Binding of peptides to MHC class I molecules (MHC-I) is essential for antigen
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …