Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications
Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
Dextromethorphan-bupropion for the treatment of depression: a systematic review of efficacy and safety in clinical trials
Background A significant proportion of adults with major depressive disorder (MDD) do not
respond to treatments which are currently used in clinical practice such as first-generation …
respond to treatments which are currently used in clinical practice such as first-generation …
Depression: Biological markers and treatment
Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …
mechanisms involved in its etiology, including inflammatory response, hypothalamic …
[HTML][HTML] Intranasal esketamine (SpravatoTM) for use in treatment-resistant depression in conjunction with an oral antidepressant
R Bahr, A Lopez, JA Rey - Pharmacy and Therapeutics, 2019 - ncbi.nlm.nih.gov
Major depressive disorder (MDD) affects more than 16 million adults each year in the United
States. 1 The incomplete response that many persons experience with current …
States. 1 The incomplete response that many persons experience with current …
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports
The real or perceived proximity to death often results in a non-ordinary state of
consciousness characterized by phenomenological features such as the perception of …
consciousness characterized by phenomenological features such as the perception of …
Evaluation of inflammatory response system (IRS) and compensatory immune response system (CIRS) in adolescent major depression
N Ferencova, Z Visnovcova, I Ondrejka… - Journal of …, 2023 - Taylor & Francis
Purpose Nowadays, the role of two tightly interconnected systems, the inflammatory
response system (IRS) and the compensatory immune response system (CIRS) in …
response system (IRS) and the compensatory immune response system (CIRS) in …
[HTML][HTML] Efficacy and safety of intranasal esketamine in treatment-resistant depression in adults: a systematic review
A Sapkota, H Khurshid, IA Qureshi, N Jahan, TR Went… - Cureus, 2021 - ncbi.nlm.nih.gov
Intranasal form of esketamine, the S-enantiomer of racemic ketamine, was approved by the
US FDA in 2019 for treatment-resistant depression (TRD) in adults. Since intranasal …
US FDA in 2019 for treatment-resistant depression (TRD) in adults. Since intranasal …
The glycine site of NMDA receptors: a target for cognitive enhancement in psychiatric disorders
B Peyrovian, JD Rosenblat, Z Pan, M Iacobucci… - Progress in Neuro …, 2019 - Elsevier
Cognitive dysfunction is a principal determinant of functional impairment in major depressive
disorder (MDD) and often persists during periods of euthymia. Abnormalities in the …
disorder (MDD) and often persists during periods of euthymia. Abnormalities in the …
Molecular mechanisms underlying the N-methyl-d-aspartate receptor antagonists: highlighting their potential for transdiagnostic therapeutics
The so-called “psychedelic renaissance” has stimulated expanded interest in several
classes of drugs that appear to possess transdiagnostic effects in the treatment of mental …
classes of drugs that appear to possess transdiagnostic effects in the treatment of mental …
Repurposing ketamine in depression and related disorders: can this enigmatic drug achieve success?
Repurposing ketamine in the therapy of depression could well represent a breakthrough in
understanding the etiology of depression. Ketamine was originally used as an anesthetic …
understanding the etiology of depression. Ketamine was originally used as an anesthetic …