Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

Formulation and applications of lipid-based nanovehicles: Spotlight on self-emulsifying systems

MM Mehanna, AT Mneimneh - Advanced Pharmaceutical …, 2020 - pmc.ncbi.nlm.nih.gov
The drug delivery investigation field is continuously widened and adapted to overcome
many factors such as poor drug solubility, absorption, rapid metabolism, the variability of …

Use of lipid nanocarriers to improve oral delivery of vitamins

CY Hsu, PW Wang, A Alalaiwe, ZC Lin, JY Fang - Nutrients, 2019 - mdpi.com
The chemical environment and enzymes in the gastrointestinal (GI) membrane limit the oral
absorption of some vitamins. The GI epithelium also contributes to the poor permeability of …

Mucoadhesive delivery system: a smart way to improve bioavailability of nutraceuticals

P Subramanian - Foods, 2021 - mdpi.com
The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability
due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been …

Pharmacokinetic aspects of nanoparticle-in-matrix drug delivery systems for oral/buccal delivery

RC Feitosa, DC Geraldes… - Frontiers in …, 2019 - frontiersin.org
Oral route maintains its predominance among the ones used for drug delivery, especially
when medicines are self-administered. If the dosage form is solid, therapy gains in dose …

Development of multi-compartment 3d-printed tablets loaded with self-nanoemulsified formulations of various drugs: A new strategy for personalized medicine

TA Ahmed, RI Felimban, HH Tayeb, WY Rizg… - Pharmaceutics, 2021 - mdpi.com
This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride
(GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes …

Self-nanoemulsifying system loaded with sildenafil citrate and incorporated within oral lyophilized flash tablets: preparation, optimization, and in vivo evaluation

KM Hosny, NA Alhakamy, MA Almodhwahi, M Kurakula… - Pharmaceutics, 2020 - mdpi.com
Sildenafil citrate is a drug used throughout the world primarily to treat erectile dysfunction.
Several problems with the commercially available product decrease its efficacy, such as …

Enhancing the antiproliferative activity of perillyl alcohol against glioblastoma cell lines through synergistic formulation with natural oils

WS Alharbi, AA Alshehri, TA Ahmed… - Current …, 2024 - benthamdirect.com
Background: Due to its volatility, photostability, and gastrointestinal toxicity, Perillyl Alcohol
(POH), a monoterpenoid component of various plant species, is a chemotherapeutic drug …

Baker-Lonsdale model of drug release

A Talevi, ME Ruiz - The ADME Encyclopedia: A Comprehensive Guide on …, 2022 - Springer
The Baker-Lonsdale model describes the drug release from spherical monolithic drug
delivery devices, in which the active pharmaceutical ingredient is initially dispersed …

Investigating the potential of transmucosal delivery of febuxostat from oral lyophilized tablets loaded with a self-nanoemulsifying delivery system

YA Al-Amodi, KM Hosny, WS Alharbi, MK Safo… - Pharmaceutics, 2020 - mdpi.com
Gout is the most familiar inflammatory arthritis condition caused by the elevation of uric acid
in the bloodstream. Febuxostat (FBX) is the latest drug approved by the United States Food …