Challenges in making ideal cryo-EM samples

BG Han, A Avila-Sakar, J Remis, RM Glaeser - Current Opinion in Structural …, 2023 - Elsevier
Recognizing that interaction with the air–water interface (AWI) is a major challenge for cryo-
EM, we first review current approaches designed to avoid it. Of these, immobilizing particles …

[HTML][HTML] Computer-aided nanodrug discovery: recent progress and future prospects

JJ Zheng, QZ Li, Z Wang, X Wang, Y Zhao… - Chemical Society …, 2024 - pubs.rsc.org
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …

Study of Friction and Wear Behavior of Graphene‐Reinforced AA7075 Nanocomposites by Machine Learning

I Prasanth, P Jeevanandam, P Selvaraju… - Journal of …, 2023 - Wiley Online Library
In this research, the friction and wear of AA7075 nanocomposites reinforced with graphene
and graphite were studied. Graphene's inclusion dramatically enhanced the material's …

Computational methods in glaucoma research: current status and future outlook

MJ Kim, CA Martin, J Kim, MM Jablonski - Molecular Aspects of Medicine, 2023 - Elsevier
Advancements in computational techniques have transformed glaucoma research, providing
a deeper understanding of genetics, disease mechanisms, and potential therapeutic targets …

Allosteric regulation in SARS-CoV-2 spike protein

Y Wei, AX Chen, Y Lin, T Wei, B Qiao - Physical Chemistry Chemical …, 2024 - pubs.rsc.org
Allosteric regulation is common in protein–protein interactions and is thus promising in drug
design. Previous experimental and simulation work supported the presence of allosteric …

Protein adsorption performance of a novel functionalized cellulose-based polymer

D Gago, MC Corvo, R Chagas, LM Ferreira, I Coelhoso - Polymers, 2022 - mdpi.com
Dicarboxymethyl cellulose (DCMC) was synthesized and tested for protein adsorption. The
prepared polymer was characterized by inductively coupled plasma atomic emission …

[HTML][HTML] Graphene in cryo-EM specimen optimization

N Liu, HW Wang - Current Opinion in Structural Biology, 2024 - Elsevier
Specimen preparation is a critical but challenging step in high-resolution cryogenic electron
microscopy (cryo-EM) structural analysis of macromolecules. In the past decade, graphene …

Nanofibrous Membranes with High Mechanical Strength for the Separation and Purification of Lysozyme

Y Peng, H Wu, J Ye, C Zheng… - ACS Applied Nano …, 2024 - ACS Publications
Developing bioseparation media with both high strength and high surface area capable of
efficiently separating proteins is a significant challenge. In this study, nanofibrous …

Hydration and Antibiofouling Behavior of Zwitterionic Polycarboxybetaine-Grafted Surfaces Studied with Atomistic Simulations

X Qin, J Fang, AA Chen, P Sarker, MSJ Sajib… - Langmuir, 2024 - ACS Publications
Fouling-resistant coating materials have important applications in marine industry and
biomedicine. Zwitterionic carboxybetaine polymers have demonstrated robust antibiofouling …

Glass Transition Temperature Prediction of Polymers via Graph Reinforcement Learning

C Dong, D Li, J Liu - Langmuir, 2024 - ACS Publications
An expansive array of graph-based models has been utilized for accurate prediction of the
structure–property relation of polymers. However, these approaches notably underutilize …