[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Stearoyl-CoA desaturase 1 as a therapeutic target for the treatment of cancer
Z Tracz-Gaszewska, P Dobrzyn - Cancers, 2019 - mdpi.com
A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …
liver. Expression is highly variable both between individuals and within individuals, owing to …
Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer
G Zhang, S Kodani, BD Hammock - Progress in lipid research, 2014 - Elsevier
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …
Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
D Panigrahy, A Kaipainen, ER Greene… - Cancer and Metastasis …, 2010 - Springer
Endogenously produced lipid autacoids are locally acting small molecule mediators that
play a central role in the regulation of inflammation and tissue homeostasis. A well-studied …
play a central role in the regulation of inflammation and tissue homeostasis. A well-studied …
EET signaling in cancer
D Panigrahy, ER Greene, A Pozzi, DW Wang… - Cancer and Metastasis …, 2011 - Springer
Inflammation and angiogenesis in the tumor microenvironment are increasingly implicated
in tumorigenesis. Endogenously produced lipid autacoids, locally acting small-molecule …
in tumorigenesis. Endogenously produced lipid autacoids, locally acting small-molecule …
Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders
Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …
epoxygenases are actively involved in the metabolism of endogenous substances, like …
Characterization and pharmacokinetics of triamcinolone acetonide-loaded liposomes topical formulations for vitreoretinal drug delivery
JC Altamirano-Vallejo, J Navarro-Partida… - Journal of Ocular …, 2018 - liebertpub.com
Purpose: To achieve a safer alternative to intravitreal injection of corticosteroids, we
developed and characterized triamcinolone acetonide-loaded liposomes formulations (TA …
developed and characterized triamcinolone acetonide-loaded liposomes formulations (TA …
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase
PC Theodoropoulos, SS Gonzales… - Nature chemical …, 2016 - nature.com
A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We
evaluated results from a viability screen of over 200,000 small molecules to identify two …
evaluated results from a viability screen of over 200,000 small molecules to identify two …