Enzymatic biotesting: scientific basis and application

EN Esimbekova, IG Torgashina, VP Kalyabina… - … problems of ecology, 2021 - Springer
The paper provides a review of the current state of research in the field of biotesting, and the
problems of environmental studies and ways to solve them are discussed. The basic …

Cadmium effects on the freshwater teleost Prochilodus lineatus: Accumulation and biochemical, genotoxic, and behavioural biomarkers

AOF da Silva, V Bezerra, PC Meletti… - Environmental …, 2023 - Elsevier
In order to evaluate the effects of Cd, juveniles of the Neotropical fish Prochilodus lineatus
were exposed to 1 and 10 μg L-1 Cd, for 24 and 96 h. Fish exposed to Cd showed metal …

Pesticide effects on fish cholinesterase variability and mean activity: A meta-analytic review

MS Santana, L Sandrini-Neto, M Di Domenico… - Science of the Total …, 2021 - Elsevier
Fish cholinesterases (ChEs)–like acetylcholinesterase (AChE) and butyrylcholinesterase
(BChE)–are common biomarkers of environmental contamination due to their sensitivity to a …

Assessment of chlorpyrifos toxic effects in zebrafish (Danio rerio) metabolism

C Gómez-Canela, E Prats, B Piña, R Tauler - Environmental Pollution, 2017 - Elsevier
In this work the effect of chlorpyrifos exposure on metabolic profiles of zebrafish muscle was
evaluated by liquid chromatography coupled to high resolution mass spectrometry. Different …

Design of bioluminescent biosensors for assessing contamination of complex matrices

EN Esimbekova, VP Kalyabina, KV Kopylova… - Talanta, 2021 - Elsevier
The presence of potentially toxic xenobiotics in complex matrices has become rather the rule
than the exception. Therefore, there is a need for highly sensitive inexpensive techniques for …

Effects of sub-lethal and chronic lead concentrations on blood and liver ALA-D activity and hematological parameters in Nile tilapia

CR Dos Santos, ALM Cavalcante… - Ecotoxicology and …, 2016 - Elsevier
Liver and blood δ-aminolevulinic acid dehydratase (ALA-D) inhibition by exposure to sub-
lethal lead concentrations over time in Nile tilapia (Oreochromis niloticus) were investigated …

Atrazine levels in the Jaboticabal water stream (São Paulo State, Brazil) and its toxicological effects on the pacu fish Piaractus mesopotamicus/Razine atrazina u …

EA dos Santos, C da Cruz, SP Carraschi… - Archives of Industrial …, 2015 - sciendo.com
The aim of this study was to determine the environmental concentration of atrazine (ATZ) in
five streams located in the north of São Paulo state (Brazil) and evaluate its toxicological …

Inihibition of mullet (M. liza) brain acetylcholinesterase activity by in vitro polycyclic aromatic hydrocarbon exposure

RA Hauser-Davis, RM Lopes, RL Ziolli - Marine pollution bulletin, 2019 - Elsevier
Polycyclic aromatic hydrocarbons (PAH) have been reported as acetylcholinesterase
(AChE) inibitors, although in vitro studies on PAH effects on AChE activity are scarce and …

[PDF][PDF] Ферментативное биотестирование: научные основы и применение

ЕН Есимбекова, ИГ Торгашина, ВП Калябина… - Сибирский …, 2021 - sibran.ru
АННОТАЦИЯ В обзоре представлен анализ современного состояния исследований в
области биотестирования, обсуждаются проблемы и способы их решения …

Synthesis, in vitro assays, molecular docking, theoretical ADMET prediction, and evaluation of 4-methoxy-phenylthiazole-2-amine derivatives as acetylcholinesterase …

XZ Zhang, Y Xu, MM Jian, K Yang, ZY Ma - Medicinal Chemistry Research, 2019 - Springer
Based on the cholinergic hypothesis of the reported compound, N-(4-(4-methoxy-phenyl)
thiazol-2-yl)-3-(pyrrolidin-1-yl) propionamide, which had a good inhibitory activity to …