Cysteine side chains can exist in distinct oxidation states depending on the pH and redox
potential of the environment, and cysteine oxidation plays important yet complex regulatory …

Many important protein functions are carried out through proton-coupled conformational
dynamics. Thus, the ability to accurately model protonation states dynamically has wide …

OmcZ nanowires produced by Geobacter species have high electron conductivity (> 30 S
cm− 1). Of 111 cytochromes present in G. sulfurreducens, OmcZ is the only known nanowire …

A micrometers-long helical homopolymer of the outer-membrane cytochrome type S (OmcS)
from Geobacter sulfurreducens is proposed to transport electrons to extracellular acceptors …

The tunable design of protein redox potentials promises to open a range of applications in
biotechnology and catalysis. Here, we introduce a method to calculate redox potential …

The development of a covalent inhibitor requires the incorporation of an appropriate
warhead into the chemical structure of the inhibitor and the selection of an appropriate …

Protons participate in many reactions. In proteins, protons need paths to move in and out of
buried active sites. The vectorial movement of protons coupled to electron transfer reactions …

Micron-scale electron transfer through polymeric cytochrome 'nanowires' powers prokaryotic
life from hydrothermal vents to terrestrial soils in ways not fully understood. How much …

The oxidation of tyrosine to form the neutral tyrosine radical via proton-coupled electron
transfer is essential for a wide range of biological processes. The precise measurement of …

A helical homopolymer of the outer-membrane cytochrome type S (OmcS) was proposed to
electrically connect a common soil bacterium, Geobacter sulfurreducens, with minerals and …