The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …

Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of
rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the …

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by destructive
hyperplasia of the synovium. Fibroblast‐like synoviocytes (FLS) are a major component of …

Extracellular DNA may serve as marker in liquid biopsies to determine individual diagnosis
and prognosis in cancer patients. Cell death or active release from various cell types …