A substantial proportion of disease risk for common complex disorders is attributable to environmental exposures and pollutants. An appreciation of how environmental pollutants …
Animal studies show aging varies between individuals as well as between organs within an individual,,–, but whether this is true in humans and its effect on age-related diseases is …
The search for biomarkers that quantify biological aging (particularly 'omic'-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
AT Lu, AM Binder, J Zhang, Q Yan, AP Reiner… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
We previously described a DNA methylation (DNAm) based biomarker of human mortality risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
J Ren, M Song, W Zhang, JP Cai, F Cao, Z Cao… - Nature Medicine, 2023 - nature.com
The global population of older peo-ple is growing at an unprecedented rate, with the number of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …
The gut microbiome is a modifier of disease risk because it interacts with nutrition, metabolism, immunity and infection. Aging-related health loss has been correlated with …
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging …
Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity and outcome. In recent years, several …
Modern health care faces several serious challenges, including an ageing population and its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …