New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
VB O'Donnell - Biochemical Society Transactions, 2022 - portlandpress.com
The Lands Pathway is a fundamental biochemical process named for its discovery by
William EM Lands and revealed in a series of seminal papers published in the Journal of …
William EM Lands and revealed in a series of seminal papers published in the Journal of …
Therapeutic opportunities for the treatment of NASH with genetically validated targets
The identification of genetic variants associated with fatty liver disease (FLD) from genome-
wide association studies started in 2008 when single nucleotide polymorphisms in PNPLA3 …
wide association studies started in 2008 when single nucleotide polymorphisms in PNPLA3 …
[HTML][HTML] Exome-wide association study on alanine aminotransferase identifies sequence variants in the GPAM and APOE associated with fatty liver disease
O Jamialahmadi, RM Mancina, E Ciociola… - Gastroenterology, 2021 - Elsevier
Background & Aims Fatty liver disease (FLD) is a growing epidemic that is expected to be
the leading cause of end-stage liver disease within the next decade. Both environmental …
the leading cause of end-stage liver disease within the next decade. Both environmental …
MBOAT7 in liver and extrahepatic diseases
MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It
has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated …
has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated …
Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease
V Varadharajan, WJ Massey, JM Brown - Journal of Lipid Research, 2022 - ASBMB
Advanced liver diseases account for approximately 2 million deaths annually worldwide.
Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and …
Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and …
Precision medicine and nucleotide-based therapeutics to treat MASH
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial
disease and becoming the leading cause of liver-related morbidity and mortality. MASLD …
disease and becoming the leading cause of liver-related morbidity and mortality. MASLD …
[HTML][HTML] LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol
Human membrane bound O-acyltransferase domain-containing 7 (MBOAT7), also known as
lysophosphatidylinositol acyltransferase 1 (LPIAT1), is an enzyme involved in the acyl-chain …
lysophosphatidylinositol acyltransferase 1 (LPIAT1), is an enzyme involved in the acyl-chain …
Lysophospholipid acyltransferases orchestrate the compositional diversity of phospholipids
Lysophospholipid acyltransferases (LPLATs), in concert with glycerol-3-phosphate
acyltransferases (GPATs) and phospholipase A 1/2 s, orchestrate the compositional diversity …
acyltransferases (GPATs) and phospholipase A 1/2 s, orchestrate the compositional diversity …
[HTML][HTML] Enhancing hepatic MBOAT7 expression in mice with nonalcoholic steatohepatitis
MC Sharpe, KD Pyles, T Hallcox, DR Kamm… - Gastro hep …, 2023 - Elsevier
Background and Aims Polymorphisms near the membrane bound O-acyltransferase domain
containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver …
containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver …
Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration
I Tang, A Nisal, A Reed, TB Ware, A Johansen… - Science Translational …, 2025 - science.org
Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder,
including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase …
including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase …