Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both
genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms …

Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …

Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Synovial tissue is a membranous non-immune organ lining joint cavities where it supports
local immune responses, and functions directly and indirectly in joint destruction due to …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate
and adaptive immune responses, inducing the priming and differentiation of naive to effector …

Cryptic peptides, hidden from the immune system under physiologic conditions, are
revealed by changes to MHC class II processing and hypothesized to drive the loss of …

Rheumatoid arthritis (RA) is characterized by synovial joint inflammation, cartilage damage,
and dysregulation of the adaptive immune system. While neutrophil extracellular traps …