Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Sex difference of colon adenoma pathway and colorectal carcinogenesis

Y Choi, N Kim - The World Journal of Men's Health, 2023 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …

The role of testosterone in colorectal carcinoma: pathomechanisms and open questions

MHK Roshan, A Tambo, NP Pace - Epma Journal, 2016 - Springer
Colorectal cancer (CRC) is the fourth commonest type of malignancy after breast, lung and
prostate in the USA and accounts for approximately 49,190 deaths annually in USA alone …

Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case–Control Study and Meta-Analysis

J Harbs, S Rinaldi, A Gicquiau… - … Biomarkers & Prevention, 2022 - AACR
Background: Endogenous sex hormones may contribute to higher colorectal cancer
incidence rates in men compared with women, but despite an increased number of studies …

Endogenous sex hormones and colorectal cancer survival among men and women

W Yang, EL Giovannucci, SE Hankinson… - … journal of cancer, 2020 - Wiley Online Library
Although previous studies have suggested a potential role of sex hormones in the etiology of
colorectal cancer (CRC), no study has yet examined the associations between circulating …

[HTML][HTML] Androgen receptor expression and bicalutamide antagonize androgen receptor inhibit β-catenin transcription complex in estrogen receptor-negative breast …

R Huang, J Han, X Liang, S Sun, Y Jiang… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Little is known about the potential mechanism of action for androgen
receptor (AR) targeting treatment in estrogen receptor (ER)-negative breast cancer. This …

Circulating sex hormone levels and colorectal cancer risk in Japanese postmenopausal women: the JPHC nested case–control study

N Mori, N Sawada, M Iwasaki, T Yamaji… - … Journal of Cancer, 2019 - Wiley Online Library
Previous epidemiological studies evaluated endogenous sex hormone levels and colorectal
cancer (CRC) risk have yielded inconsistent results. Also, it is unknown if consumption of …

A protective role for androgen receptor in clear cell renal cell carcinoma based on mining TCGA data

H Zhao, JT Leppert, DM Peehl - PLoS One, 2016 - journals.plos.org
Androgen receptor (AR) is expressed in normal murine and human kidneys of both genders,
but its physiologic role is uncertain. Several studies showed loss of AR in renal cell …

Steroid 5α-reductase type I induces cell viability and migration via nuclear factor-κB/vascular endothelial growth factor signaling pathway in colorectal cancer

R Wei, S Zhong, L Qiao, M Guo, M Shao… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) is a common malignant tumor of the digestive system. Steroid 5α-
reductase type I (SRD5A1), as an important part of the steroid metabolism, converts …

Androgen receptor gene methylation related to colorectal cancer risk

T Xia, H Sun, H Huang, H Bi, R Pu… - Endocrine …, 2019 - ec.bioscientifica.com
According to its incidence patterns, colorectal cancer (CRC) tends to occur more frequently
in males than in females, and the evidence shows that CRC is a hormone-related tumor …