Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Cryptic pockets expand the scope of drug discovery by enabling targeting of proteins
currently considered undruggable because they lack pockets in their ground state structures …

▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number …

Compared to the other glutamate receptors, progress in the understanding of the functions of
kainate receptors (KARs) has lagged behind, due mainly to the relative lack of specific …

Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is
believed to have complex genetic and environmental influences in the pathogenesis, but …

Glutamate receptor ion channels mediate excitatory responses at the majority of CNS
synapses. They are the only ligand-gated ion channels for which multiple high-resolution …

The orphan glutamate-like receptor GluRδ2 is predominantly expressed in Purkinje cells of
the central nervous system. The classification of GluRδ2 to the ionotropic glutamate receptor …

This volume in the Chemistry of Heterocyclic Compounds series presents a comprehensive
review of the quinoxaline literature from 1975 to the present (2002), updating Volumes 5 and …

Ionotropic glutamate receptors are tetramers, the isolated ligand binding cores of which
assemble as dimers. Previous work on nondesensitizing AMPA receptor mutants, which …