MAIT cells in health and disease

NM Provine, P Klenerman - Annual review of immunology, 2020 - annualreviews.org
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over
the last few years as a potent unconventional T cell subset. Three factors largely account for …

MAIT cells and viruses

JE Ussher, CB Willberg… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that
specifically targets microbially derived metabolites. Functionally, they respond to bacteria …

[HTML][HTML] TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses

R Lamichhane, M Schneider, SM de la Harpe… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …

The CD4CD8 MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool

J Dias, C Boulouis, JB Gorin… - Proceedings of the …, 2018 - National Acad Sciences
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that
recognize microbial riboflavin metabolites presented by the MHC class I-like protein MR1 …

A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa

O Jensen, S Trivedi, JD Meier, KC Fairfax, JS Hale… - Science …, 2022 - science.org
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that aid in
protection against bacterial pathogens at mucosal surfaces through the release of …

[HTML][HTML] MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

TE Pankhurst, KH Buick, JL Lange, AJ Marshall… - Cell Reports, 2023 - cell.com
Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

MNT Souter, W Awad, S Li, TJ Pediongco… - Journal of Experimental …, 2022 - rupress.org
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …

[HTML][HTML] Insights into mucosal-associated invariant T cell biology from studies of invariant natural killer T cells

LC Garner, P Klenerman, NM Provine - Frontiers in immunology, 2018 - frontiersin.org
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are
innate-like T cells that function at the interface between innate and adaptive immunity. They …

[HTML][HTML] MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine

C Boulouis, T Kammann, A Cuapio, T Parrot, Y Gao… - Molecular …, 2022 - Springer
Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like
capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition …

Viral respiratory pathogens and lung injury

N Clementi, S Ghosh, M De Santis… - Clinical microbiology …, 2021 - Am Soc Microbiol
Several viruses target the human respiratory tract, causing different clinical manifestations
spanning from mild upper airway involvement to life-threatening acute respiratory distress …