The influenza virus RNA polymerase as an innate immune agonist and antagonist

E Elshina, AJW Te Velthuis - Cellular and Molecular Life Sciences, 2021 - Springer
Influenza A viruses cause a mild-to-severe respiratory disease that affects millions of people
each year. One of the many determinants of disease outcome is the innate immune …

Single-cycle influenza virus vaccine generates lung CD8+ Trm that cross-react against viral variants and subvert virus escape mutants

MZM Zheng, TK Tan, F Villalon-Letelier, H Lau… - Science …, 2023 - science.org
Influenza virus–specific tissue-resident memory (Trm) CD8+ T cells located along the
respiratory tract provide cross-strain protection against a breadth of influenza viruses. We …

The ubiquitination landscape of the influenza A virus polymerase

F Günl, T Krischuns, JA Schreiber, L Henschel… - Nature …, 2023 - nature.com
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for
modification with ubiquitin. Here, we decipher and functionally explore the ubiquitination …

Next-generation T cell–activating vaccination increases influenza virus mutation prevalence

MB Bull, H Gu, FNL Ma, LP Perera, LLM Poon… - Science …, 2022 - science.org
To determine the potential for viral adaptation to T cell responses, we probed the full
influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in …

[PDF][PDF] Detection and treatment strategies for influenza viruses with reduced susceptibility to baloxavir marboxil

PA Koszalka - 2022 - scholar.archive.org
Influenza viruses circulate globally and lead to seasonal epidemics and occasionally
pandemics. In humans the virus causes a respiratory illness, a cough often with fever are the …