Abstract Histone deacetylase 3 (HDAC3) is a critical regulator of gene expression,
influencing a variety of cellular processes in the central nervous system. As such …

Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to
metabolic disorders and neurodegenerative diseases. In primary mitochondrial disorders …

Substantial advances in technology are permitting a high resolution understanding of the
salience of glia, and have helped us to transcend decades of predominantly neuron‐centric …

HDAC3 inhibition has been shown to improve memory and reduce amyloid‐β (Aβ) in
Alzheimer's disease (AD) models, but the underlying mechanisms are unclear. We …

Astrocyte morphology in vivo is heterogeneous across different subtypes and dynamically
changes in response to various stimuli. However, several questions on the mechanistic links …

Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy.
However, a limitation of AAV-mediated gene therapy is that patients are typically dosed only …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the most
common cause of dementia. Despite its prevalence, there are a lack of effective disease …

A crescente prevalência dos comportamentos aditivos não apenas relacionados a
substâncias, mas também a jogos, uso de internet e redes sociais, impacta diretamente …

A strocytes quickly respond to trouble in the brain. Under normal physiological conditions,
these abundant reactive glial cells rapidly adapt to environmental changes, which allows …

Central nervous system (CNS) drug development is plagued by high clinical failure rate.
Phenotypic assays promote clinical translation of drugs by reducing complex brain diseases …