A critical review of radiation therapy: from particle beam therapy (proton, carbon, and BNCT) to beyond

Y Matsumoto, N Fukumitsu, H Ishikawa… - Journal of personalized …, 2021 - mdpi.com
In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has
shown rapid progress and widespread use in recent years—in multidisciplinary treatment …

[HTML][HTML] Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer …

K Hirose, A Konno, J Hiratsuka, S Yoshimoto… - Radiotherapy and …, 2021 - Elsevier
Background and purpose Boron neutron capture therapy (BNCT) can be performed without
reactors due to development of cyclotron-based epithermal neutron source (C-BENS), which …

Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study

K Hirose, M Sato, T Kato, K Takayama… - Journal of Radiation …, 2022 - academic.oup.com
The purpose of this study was to outline the course and profile of adverse events specific to
boron neutron capture therapy (BNCT) for head and neck cancer. This was a sub-analysis of …

A novel approach to design and evaluate BNCT neutron beams combining physical, radiobiological, and dosimetric figures of merit

I Postuma, S González, MS Herrera, L Provenzano… - Biology, 2021 - mdpi.com
Simple Summary Clinical potential and safety are presented as novel criteria to evaluate
neutron beams designed for boron neutron capture therapy (BNCT). The presently used …

Detailed dosimetry calculation for in-vitro experiments and its impact on clinical BNCT

AMD Viegas, I Postuma, S Bortolussi, C Guidi… - Physica Medica, 2021 - Elsevier
Abstract Purpose Boron Neutron Capture Therapy (BNCT) is a form of hadrontherapy based
on the selective damage caused by the products of neutron capture in 10 B to tumour cells …

Evaluating the biological effectiveness of boron neutron capture therapy by using microfluidics-based pancreatic tumor spheroids

LY Yu, CH Hsu, CY Li, SY Hong, CR Chen, CS Chen - Analyst, 2023 - pubs.rsc.org
Background: The recent success of boron neutron capture therapy (BNCT) for cancer
treatment has attracted considerable attention. Because irradiated neutrons penetrate deep …

Using the photon isoeffective dose formalism to compare and combine BNCT and CIRT in a head and neck tumour

I Postuma, C Magni, B Marcaccio, S Fatemi… - Scientific Reports, 2024 - nature.com
Abstract Boron Neutron Capture Therapy (BNCT) is a radiotherapy technique based on the
enrichment of tumour cells with suitable 10-boron concentration and on subsequent neutron …

Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit

J Chen, Z Hu, J Tong, B Zhou, R Zhang, C Zhao… - Nuclear Instruments and …, 2021 - Elsevier
This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is
appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of …

Evaluating the therapeutic potential and the suitability of neutron beams designed for clinical BNCT

I Postuma, S Gonzalez, M Herrera, L Provenzano… - 2020 - researchsquare.com
The standard of neutron beam quality for Boron Neutron Capture Therapy (BNCT) of deep-
seated tumours is currently defined by its physical characteristics in air: the epithermal …

Using the photon isoeffective dose formalism to compare and combine BNCT and carbon-ion radiotherapy: an example of head and neck tumour

I Postuma, C Magni, B Marcaccio, S Fatemi, V Vercesi… - 2023 - researchsquare.com
Abstract Boron Neutron Capture Therapy (BNCT) is a radiotherapy technique based on the
enrichment of tumour cells with suitable10-boron concentration and on subsequent neutron …