Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Polycomb group (PcG) proteins repress master regulators of development and differentiation
through organization of chromatin structure. Mutation and dysregulation of PcG genes cause …

Single-particle tracking (SPT) has become an important method to bridge biochemistry and
cell biology since it allows direct observation of protein binding and diffusion dynamics in …

Compartmentalization by liquid-liquid phase separation is implicated in transcription. It
remains unclear whether and how transcriptional condensates accelerate the search of …

Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Polycomb repressive complexes (PRCs) play a key role in gene repression and are
indispensable for proper development. Canonical PRC1 forms condensates in vitro and in …

Abstract Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to
mark genes for repression. We measured the dynamics of PRC2 binding on recombinant …