In the past few decades, drug metabolism research has played an ever increasing role in the
design of drugs. 1− 3 In vitro metabolism assays 4 have become an integral part of the …

The imidazo [1, 2-a] pyridine scaffold is recognized as a privileged structure as it represents
a promising area for identification of lead structures towards the discovery of new synthetic …

Shorter reaction times, higher product yields, and enhanced selectivity are some of the
advantages microwave heating has over conventional methods, causing its use to transition …

A series of nine novel imidazo [1, 2-a] pyridin-chromones and nine novel imidazo [1, 2-a]
pyridin-6-fluorochromones were synthesized in good to excellent yields by a MW assisted …

Introduction: H+/K+-ATPase is a P-type ATP-driven cation transporter which exchanges ions
(protons, chloride ions, and potassium ions) across the cell membrane. Modulators of H+/K+ …

Publisher Summary This chapter describes the synthesis and chemistry of six-membered
ring systems, particularly pyridines and benzo derivatives. Pyridine and pyridine-derived …

A series of aromatic heterocycles, thiazoles, imidazoles, and dimethoxyindoles, can be
synthesised directly from alkenes via a ketoiodination-cyclisation protocol. The alkene …

2 460 805 A 2 651 944 Al WO 94/11026 A2 WO 99/050461 Al WO 00/056729 AL WO
01/085196 A2 WO 01/094420 Al WO 03/090512 A2 WO 2007/095594 A2 WO 2010/059401 …

A variety of basic, heterocyclic templates has been reported as potassium-competitive, acid
pump antagonists. Herein, we report a comparison of potencies of these templates and …

Pseudouridine (ψ-uridine, Ψ) aza′-analogues with a 5, 5-bis (hydroxymethyl)-1-pyrrolin-2-
yl 1-oxide as the glycone mimic were obtained by the addition of (2, 4-dimethoxypyrimidin-5 …