Industrial natural product chemistry for drug discovery and development
A Bauer, M Brönstrup - Natural product reports, 2014 - pubs.rsc.org
Covering: up to March 2013 In addition to their prominent role in basic biological and
chemical research, natural products are a rich source of commercial products for the …
chemical research, natural products are a rich source of commercial products for the …
Hypervalent iodine reagents in the total synthesis of natural products
LF Silva Jr, B Olofsson - Natural product reports, 2011 - pubs.rsc.org
Covering: 2008–2010 This report describes the recent applications of hypervalent iodine
reagents in the total synthesis of natural products. The large diversity of high-yielding and …
reagents in the total synthesis of natural products. The large diversity of high-yielding and …
Vinyl epoxides in organic synthesis
Vinyl epoxides are molecules with a rich chemistry because of the strained oxirane, already
a reactive moiety on its own, in proximity with a carbon− carbon double bond. The chemistry …
a reactive moiety on its own, in proximity with a carbon− carbon double bond. The chemistry …
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance
KC Nicolaou, CRH Hale, C Nilewski… - Chemical Society …, 2012 - pubs.rsc.org
The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …
the nineteenth century and were refined in the twentieth century constitute two of the most …
Synthetic opportunities and challenges for macrocyclic kinase inhibitors
Macrocycles are typically cyclic variants of inhibitors derived from uncyclized canonical
molecules or from natural products. For medicinal chemistry, drug-like macrocycles have …
molecules or from natural products. For medicinal chemistry, drug-like macrocycles have …
Cobalt-Catalyzed Enantioselective Hydroboration of α-Substituted Acrylates
Even though metal-catalyzed enantioselective hydroborations of alkenes have attracted
enormous attention, few preparatively useful reactions of α-alkyl acrylic acid derivatives are …
enormous attention, few preparatively useful reactions of α-alkyl acrylic acid derivatives are …
Still–Gennari Olefination and its applications in organic synthesis
I Janicki, P Kiełbasiński - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
Abstract The Still–Gennari olefination is a widely applied modification of the Horner–
Wadsworth–Emmons reaction, allowing access to Z‐olefins by carbonyl group …
Wadsworth–Emmons reaction, allowing access to Z‐olefins by carbonyl group …
Tin-mediated regioselective benzylation and allylation of polyols: applicability of a catalytic approach under solvent-free conditions
M Giordano, A Iadonisi - The Journal of Organic Chemistry, 2014 - ACS Publications
The first catalytic version of the stannylene-mediated benzylation and allylation of polyols is
reported. The methodology is based on a simple solvent-free protocol that significantly …
reported. The methodology is based on a simple solvent-free protocol that significantly …
Amphidinolides F and C2: An Odyssey in Total Synthesis
L Ferrié, I Ciss, J Fenneteau, S Vallerotto… - The Journal of …, 2022 - ACS Publications
Amphidinolides F, C, C2, and C3 are marine natural products isolated from dinoflagellates
Amphidinium species. They share the same macrolactone core, with the difference between …
Amphidinium species. They share the same macrolactone core, with the difference between …
Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase
BJC Law, AW Struck, MR Bennett, B Wilkinson… - Chemical …, 2015 - pubs.rsc.org
The methylation of natural products by S-adenosyl methionine (AdoMet, also known as
SAM)-dependent methyltransferase enzymes is a common tailoring step in many …
SAM)-dependent methyltransferase enzymes is a common tailoring step in many …