The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and
pattern of the muscle activity underlying locomotion in mammals. This review discusses new …

Within the vertebrate nervous system, the presence of many different lineages of neurons
and glia complicates the molecular characterization of single neuronal populations. In order …

The corticospinal system is the principal motor system for controlling movements that require
the greatest skill and flexibility. It is the last motor system to develop. The pattern of …

Spinal cord injury usually results in permanent paralysis because of lack of regrowth of
damaged neurons. Here we demonstrate that adult mice lacking EphA4 (-/-), a molecule …

The establishment of functional neural circuits requires the guidance of axons in response to
the actions of secreted and cell-surface molecules such as the semaphorins. Semaphorin …

The basic motor patterns underlying rhythmic limb movements during locomotion are
generated by neuronal networks located within the spinal cord. These networks are called …

Angiogenesis is critical for vascular remodeling during development and contributes to the
pathogenesis of diseases such as cancer. Targeted disruption of several EphB class …

Injury to the central nervous system (CNS) usually results in very limited regeneration of
lesioned axons, which are inhibited by the environment of the injury site. Factors that have …

The corticospinal (CS) system, critical for controlling skilled movements, develops during the
late prenatal and early postnatal periods in all species examined. In the cat, there is a …