Molecular dynamics simulations of membrane permeability
This Review illustrates the evaluation of permeability of lipid membranes from molecular
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
[HTML][HTML] The skin barrier: an extraordinary interface with an exceptional lipid organization
The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
[HTML][HTML] The heterogeneity and complexity of skin surface lipids in human skin health and disease
D Mijaljica, JP Townley, F Spada, IP Harrison - Progress in lipid research, 2024 - Elsevier
The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …
[HTML][HTML] The stratum corneum barrier-from molecular scale to macroscopic properties
The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines
mechanical strength with efficient barrier function. In this paper, we discuss these …
mechanical strength with efficient barrier function. In this paper, we discuss these …
Using molecular simulation to understand the skin barrier
Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …
Protective barriers provided by the epidermis
S de Szalay, PW Wertz - International Journal of Molecular Sciences, 2023 - mdpi.com
The skin is the largest organ of the body and consists of an epidermis, dermis and
subcutaneous adipose tissue. The skin surface area is often stated to be about 1.8 to 2 m2 …
subcutaneous adipose tissue. The skin surface area is often stated to be about 1.8 to 2 m2 …
Roles of lipids in the permeability barriers of skin and oral mucosa
PW Wertz - International Journal of Molecular Sciences, 2021 - mdpi.com
PubMed searches reveal much literature regarding lipids in barrier function of skin and less
literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and …
literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and …
Ceramic microneedles and hollow microneedles for transdermal drug delivery: Two decades of research
K Ita - Journal of Drug Delivery Science and Technology, 2018 - Elsevier
There are exciting developments in the research domain regarding the use of ceramic
microneedles (CMs) and hollow microneedles (HMNs) for transdermal drug delivery …
microneedles (CMs) and hollow microneedles (HMNs) for transdermal drug delivery …
[HTML][HTML] Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation
M Lundborg, A Narangifard, CL Wennberg… - Journal of structural …, 2018 - Elsevier
In the present study we have analyzed the molecular structure and function of the human
skin's permeability barrier using molecular dynamics simulation validated against cryo …
skin's permeability barrier using molecular dynamics simulation validated against cryo …
Increased levels of short-chain ceramides modify the lipid organization and reduce the lipid barrier of skin model membranes
LE Uche, GS Gooris, JA Bouwstra, CM Beddoes - Langmuir, 2021 - ACS Publications
The skin barrier function is attributed to the stratum corneum (SC) intercellular lipid matrix,
which is composed primarily of ceramides (CERs), free fatty acids, and cholesterol. These …
which is composed primarily of ceramides (CERs), free fatty acids, and cholesterol. These …