Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants

KF Zahra, R Lefter, A Ali, EC Abdellah… - Oxidative Medicine …, 2021 - Wiley Online Library
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …

Antioxidants with two faces toward cancer

N Dastmalchi, B Baradaran, S Latifi-Navid… - Life Sciences, 2020 - Elsevier
Antioxidants are essential in preventing the formation and suppressing the activities of
reactive nitrogen and oxygen species. The aim of this study was to review the role of …

High Concentrations of Genistein Decrease Cell Viability Depending on Oxidative Stress and Inflammation in Colon Cancer Cell Lines

M Alorda-Clara, M Torrens-Mas… - International journal of …, 2022 - mdpi.com
Genistein could play a crucial role in modulating three closely linked physiological
processes altered during cancer: oxidative stress, mitochondrial biogenesis, and …

The ethanol-extracted polysaccharide from Cynanchum paniculatum: Optimization, structure, antioxidant and antitumor effects

H Ji, K Dai, C Liu, J Yu, A Liu, Y Chen - Industrial Crops and Products, 2022 - Elsevier
Cynanchum paniculatum has been applied for various diseases treatments, however, the
polysaccharide components especially extracted using ethanol were rarely researched. In …

Mitochondrial sirtuins in chronic degenerative diseases: new metabolic targets in colorectal cancer

A Colloca, A Balestrieri, C Anastasio… - International Journal of …, 2022 - mdpi.com
Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven
members, widely expressed in mammals. SIRTs mainly participate in metabolic …

Glutathione Reductase Expression and Its Prognostic Significance in Colon Cancer

M Brzozowa-Zasada, A Piecuch… - International Journal of …, 2024 - mdpi.com
Maintaining a balanced redox state within cells is crucial for the sustenance of life. The
process involves continuous cytosolic disulfide reduction reactions to restore oxidized …

A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer

M Brzozowa-Zasada, A Piecuch… - International Journal of …, 2024 - mdpi.com
Glutaredoxin 1 (Grx1) is an essential enzyme that regulates redox signal transduction and
repairs protein oxidation by reversing S-glutathionylation, an oxidative modification of …

Antioxidant Enzymes and Their Potential Use in Breast Cancer Treatment

MM Vilchis-Landeros, H Vázquez-Meza… - International Journal of …, 2024 - mdpi.com
According to the World Health Organization (WHO), breast cancer (BC) is the deadliest and
the most common type of cancer worldwide in women. Several factors associated with BC …

Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences

Y Chang, F Li, Z Wang, Q Zhao, Z Wang… - Frontiers in …, 2024 - frontiersin.org
Background The Oxidative Balance Score (OBS) is commonly used to assess oxidative
stress and provides a comprehensive evaluation of dietary and lifestyle-related exposures …