[HTML][HTML] GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

X Ma, Z Liu, I Ilyas, PJ Little, D Kamato… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD),
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …

Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets

CJA Ramachandra, S Cong, X Chan, EP Yap… - Free Radical Biology …, 2021 - Elsevier
When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

Effects of SGLT2 inhibitors and GLP-1 receptor agonists on renin-angiotensin-aldosterone system

S Puglisi, A Rossini, R Poli, F Dughera, A Pia… - Frontiers in …, 2021 - frontiersin.org
Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-
RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in …

Yin and yang of NADPH oxidases in myocardial ischemia-reperfusion

S Matsushima, J Sadoshima - Antioxidants, 2022 - mdpi.com
Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-
reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen …

RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function

C Shiraishi, A Matsumoto, K Ichihara… - Nature …, 2023 - nature.com
Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how
these proteins affect translation and why they are required only in certain tissues have …

Left ventricular hypertrophy in diabetic cardiomyopathy: a target for intervention

M Mohan, A Dihoum, IR Mordi, AM Choy… - Frontiers in …, 2021 - frontiersin.org
Heart failure is an important manifestation of diabetic heart disease. Before the development
of symptomatic heart failure, as much as 50% of patients with type 2 diabetes mellitus …

Efficacy and cardiovascular safety of DPP-4 inhibitors

NA Subrahmanyan, RM Koshy, K Jacob… - Current Drug …, 2021 - ingentaconnect.com
Dipeptidyl peptidase-4 (DPP-4) inhibitors or gliptins belong to the class of incretin mimetics.
These drugs have been available on the market for the management of type 2 diabetes …

NOX-dependent signaling dysregulation in severe COVID-19: clues to effective treatments

S Damiano, C Sozio, G La Rosa… - Frontiers in cellular and …, 2020 - frontiersin.org
The ongoing pandemic disease named by the World Health Organization (WHO)
coronavirus disease 2019 (COVID-19), is caused by Severe Acute Respiratory Syndrome …

Suppression of angiotensin II-activated NOX4/NADPH oxidase and mitochondrial dysfunction by preserving glucagon-like peptide-1 attenuates myocardial fibrosis …

TE Banks, M Rajapaksha, LH Zhang, F Bai… - European Journal of …, 2022 - Elsevier
This study aims to investigate whether stabilization of glucagon-like peptide-1 (GLP-1) level
reduces angiotensin II (Ang II)-induced cardiac fibrosis and-elevated blood pressure …

Neuregulin-1β improves uremic cardiomyopathy and renal dysfunction in rats

M Sárközy, S Watzinger, ZZA Kovács, E Acar… - Basic to Translational …, 2023 - jacc.org
Chronic kidney disease is a global health problem affecting 10% to 12% of the population.
Uremic cardiomyopathy is often characterized by left ventricular hypertrophy, fibrosis, and …