In the last 20 or so years, the influence of endophytes and, quite recently, epiphytes of plants
upon the compounds found in those plants, which were usually assumed to be …

Neutrophils are a type of lymphocyte involved in innate immune defense. In response to
specific stimuli, these phagocytic cells undergo a unique form of cell death, NETosis, during …

Combretastatin A-4 (CA-4) in phosphate and serine pro-drug forms is under phase II clinical
trials. With our interest of discovering CA-4 inspired new chemical entities, a novel series of …

Crocin, a component of saffron spice, is known to have an anticancer activity. However, the
targets of crocin are not known. In this study, crocin was found to inhibit the proliferation of …

Heliotropium is a genus of the Boraginaceae family. Its members are used in many
traditional and folklore medicines to treat several ailments. Despite this widespread usage …

DM1, a maytansine derivative, is a highly potential cytotoxic agent but with severe side
effects; therefore, its application in clinical cancer therapy is limited. Here, in order to mitigate …

Visceral leishmaniasis affects people from 70 countries worldwide, mostly from Indian,
African and south American continent. The increasing resistance to antimonial, miltefosine …

This research aimed to prepare a camptothecin (CPT) loaded self nano emulsifying drug
delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 3 2 full …

Agents targeting colchicine-binding pocket usually show a minimal drug-resistance issue,
albeit often associated with high toxicity. Chalcone-based compounds, which may bind to …

In addition to direct tumor cell cytotoxicity, chemotherapy can mediate tumor reduction
through immune modulation of the tumor microenvironment to promote anti-tumor immunity …