Introduction Selective serotonin reuptake inhibitors (SSRIs) and, to a lesser extent, serotonin‐
norepinephrine reuptake inhibitors (SNRIs) are the cornerstone of pharmacotherapy for …

Introduction Migraine prophylactic therapy has changed over recent years with the
development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene …

Background Patients with depression who are treated in primary care practices may receive
antidepressants for prolonged periods. Data are limited on the effects of maintaining or …

Importance There is significant concern regarding increasing long-term antidepressant
treatment for depression beyond an evidence-based duration. Objective To determine …

Brain imaging techniques enable the visualization of serotonin transporter (SERT)
occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given …

Introduction Evidence is lacking on withdrawal syndrome related to individual
antidepressants and relevant risk factors for severe reactions. Objective To ascertain …

Background: Tapering and discontinuing antidepressants are important aspects of the
management of patients with depression and should therefore be considered in clinical …

Résumé Contexte Le Réseau canadien pour les traitements de l'humeur et de l'anxiété
(CANMAT) a publié les dernières lignes directrices cliniques pour le traitement du trouble …

Background: Tapering strips facilitate antidepressant discontinuation, allowing for
personalised titration of discontinuation to the intensity of withdrawal. A tapering strip …

The ultimate goal of depression treatment is to achieve functional recovery. Psychosocial
functioning is the main component of functional impairment in depressed patients. The …