Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

The transport and sorting of lipids from the sites of their synthesis to their appropriate
destinations are fundamental for membrane biogenesis. In the synthesis of sphingolipids in …

The transport and sorting of lipids are fundamental to membrane biogenesis. In the
synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the …

Sphingolipids are a class of essential lipids implicated in constructing cellular membranes
and regulating nearly all cellular functions. Sphingolipid metabolic network is centered with …

Craniofacial and skeletal dysmorphologies account for the majority of birth defects. A
number of the disease phenotypes have been attributed to abnormal synthesis …

Lipid transfer proteins mediate inter-organelle transport of membrane lipids at organelle
contact sites in cells, playing fundamental roles in the lipidome and membrane biogenesis in …

Anderson disease (ANDD) or chylomicron retention disease (CMRD) is a rare, hereditary
lipid malabsorption syndrome associated with mutations in the SAR1B gene that is …

Sec13 is a dual function protein, being a core component of both the COPII coat, which
mediates protein trafficking from the endoplasmic reticulum to the Golgi apparatus, and the …

A BRET system is described, in which Nanoluciferase was fused to the lipid transfer protein
CERT for efficient energy transfer to a Nile red‐labeled ceramide, which is either directly …