Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Liquid phase partitioning in virus replication: observations and opportunities

C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Deconstructing virus condensation

N Lopez, G Camporeale, M Salgueiro… - PLoS …, 2021 - journals.plos.org
Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …

Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries

Y Hong, Y Song, Z Zhang, S Li - Annual Review of Biophysics, 2023 - annualreviews.org
The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-
ET resolution revolution. Meanwhile, significant efforts have been made to improve the …

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

XD Fang, Q Gao, Y Zang, JH Qiao, DM Gao, WY Xu… - Elife, 2022 - elifesciences.org
Liquid-liquid phase separation (LLPS) plays important roles in forming cellular
membraneless organelles. However, how host factors regulate LLPS of viral proteins during …

Liquid-liquid phase separation: Unraveling the enigma of biomolecular condensates in microbial cells

Z Gao, W Zhang, R Chang, S Zhang, G Yang… - Frontiers in …, 2021 - frontiersin.org
Numerous examples of microbial phase-separated biomolecular condensates have now
been identified following advances in fluorescence imaging and single molecule microscopy …

A viral biomolecular condensate coordinates assembly of progeny particles

M Charman, N Grams, N Kumar, E Halko, JM Dybas… - Nature, 2023 - nature.com
Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes,. Emerging evidence has suggested that membraneless subcellular …

[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell Reports, 2023 - cell.com
The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …

New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021 - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Actomyosin‐driven motility and coalescence of phase‐separated viral inclusion bodies are required for efficient replication of a plant rhabdovirus

Y Liang, X Zhang, B Wu, S Wang, L Kang… - New …, 2023 - Wiley Online Library
Phase separation has emerged as a fundamental principle for organizing viral and cellular
membraneless organelles. Although these subcellular compartments have been recognized …