Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

Diabetes is a group of metabolic diseases characterised by chronic hyperglycaemia caused
by multiple causes, which is caused by insulin secretion and/or utilisation defects. It is …

The kidneys are vulnerable to toxicity and acute kidney injury (AKI) is the main adverse
effect associated with the clinical use of the chemotherapeutic agent cisplatin (CIS) …

Pancreatitis is a serious effect of the heavy metal cadmium (Cd) and inflammation and
oxidative stress (OS) are implicated in Cd-induced pancreatic injury. This study evaluated …

Background Agomelatine has been shown to be effective in the treatment of depression, but
the molecular mechanisms underlying its antidepressant effects have yet to be elucidated …

Bee products are a promising source of phenolic compounds with strong antioxidant activity.
The present study was designed to explore the protective effect of honey, propolis, and their …

Chlorpyrifos (CPF) is a widely used broad-spectrum pesticide with multi-organ toxic effects.
Oxidative stress was found to play a role in the deleterious effects of CPF, including …

Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin
(CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung …

Cisplatin (CIS) is an effective chemotherapeutic drug used for the treatment of many types of
cancers, but its use is associated with adverse effects. Nephrotoxicity is a serious side effect …

The potential use of agomelatine as an alternative treatment for colorectal cancer is
evaluated in this work. The effect of agomelatine was studied in an in vitro model using two …