Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Heterochromatin protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal
protein that is prominently associated with pericentric heterochromatin and mediates the …

Aims: Vitamin C (ascorbic acid) is thought to enhance immune function, but the mechanisms
involved are obscure. We utilized an in vitro model of T-cell maturation to evaluate the role of …

Secondary metabolite biosynthesis genes in fungi are usually physically linked and
organized in large gene clusters. The physical linkage of genes involved in the same …

Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA
repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are …

The filamentous fungus Neurospora crassa has provided a rich source of knowledge on
epigenetic phenomena that would have been difficult or impossible to gain from other …

Methylated lysine 27 on histone H3 (H3K27me) marks repressed “facultative
heterochromatin,” including developmentally regulated genes in plants and animals. The …

Background Supernumerary chromosomes have been found in many organisms. In fungi,
these “accessory” or “dispensable” chromosomes are present at different frequencies in …

Although the recruitment of fibroblasts to areas of injury is critical for wound healing, their
subsequent apoptosis is necessary in order to prevent excessive scarring. Fibroproliferative …