We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent
computational and experimental studies have demonstrated that activity patterns in recurrent …

In neural circuits, individual neurons often make projections onto multiple postsynaptic
partners. Here, we investigate molecular mechanisms by which these divergent connections …

After the generation, differentiation and integration into functional circuitry, post-mitotic
neurons continue to change certain phenotypic properties throughout postnatal juvenile …

Regardless of how a nervous system is genetically built, natural selection is acting on the
functional outcome of its activity. To understand how nervous systems evolve, it is essential …

Dendritic spines are specialized postsynaptic structures that transduce presynaptic signals,
are regulated by neural activity and correlated with learning and memory. Most studies of …

GFP labeling by genome editing can reveal the authentic location of a native protein, but is
frequently hampered by weak GFP signals and broad expression across a range of tissues …

Both transcriptional regulation and signaling pathways play crucial roles in neuronal
differentiation and plasticity. Caenorhabditis elegans possesses 19 GABAergic motor …

Genetic programming and neural activity drive synaptic remodeling in developing neural
circuits, but the molecular components that link these pathways are poorly understood. Here …