Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

Cancer is the result of the progressive acquisition of multiple malignant traits through the
accumulation of genetic or epigenetic alterations. Recent studies have established a …

Abstract α-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression
drives the pathogenesis of various cancers. ENO1 has been indicated as having additional …

Tumor metastasis involves a series of biological steps during which the tumor cells acquire
the ability to invade surrounding tissues and survive outside the original tumor site. During …

MicroRNAs (miRNAs) are believed to have fundamental roles in tumorigenesis and have
great potential for the diagnosis and treatment of cancer. However, the roles of miRNAs in …

Hepatocytes function largely through the secretion of proteins that regulate cell proliferation,
metabolism, and intercellular communications. During the progression of hepatocellular …

The role of miR-26a in carcinogenesis appears to be a complicated one, in the sense that
both oncogenic and tumor suppressive effects were reported in cancers such as …

The strength and duration of NF-κB signaling are tightly controlled by multiple negative
feedback mechanisms. However, in cancer cells, these feedback loops are overridden …

Purpose: The present study was to examine the effect of sphingosine kinase-1 (SPHK1) on
chemotherapeutics-induced apoptosis in non–small cell lung cancer (NSCLC) cells, which …

FOXO transcription factors are key tumor suppressors in mammalian cells. Until now,
suppression of FOXOs in cancer cells was thought to be mainly due to activation of multiple …