[HTML][HTML] Aestivation in nature: physiological strategies and evolutionary adaptations in hypometabolic states

C Jiang, KB Storey, H Yang, L Sun - International Journal of Molecular …, 2023 - mdpi.com
Aestivation is considered to be one of the “purest” hypometabolic states in nature, as it
involves aerobic dormancy that can be induced and sustained without complex factors …

Hypermethylation‐mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a

F Wang, X Chen, B Sun, Y Ma, W Niu… - Journal of cellular …, 2021 - Wiley Online Library
Long noncoding RNA PVT1 is involved in the progression of female gynecological cancers.
However, the role of PVT1 in ovarian granulosa cell apoptosis‐mediated premature ovarian …

Activation of aryl hydrocarbon receptor signaling by gallic acid suppresses progression of human breast cancer in vitro and in vivo

H Hanieh, HIM Ibrahim, M Mohammed, OI Alwassil… - Phytomedicine, 2022 - Elsevier
Background Despite the significant advances in diagnosis and treatment, breast cancer
remains the most common malignancy and the second cause of death in women …

[PDF][PDF] Deacetylation of FOXO4 by Sirt1 stabilizes chondrocyte extracellular matrix upon activating SOX9.

ZX Ma, H Xu, W Xiang, J Qi, YY Xu… - European Review for …, 2021 - europeanreview.org
OBJECTIVE: FOXO4 has essential roles in cellular metabolism and prevents cartilage
degeneration in osteoarthritis (OA). Here we aim to provide evidence that deacetylated …

A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo

MS Abduh, OI Alwassil, SM Aldaqal… - Biochemical …, 2024 - Elsevier
Breast cancer is one of the main causes of malignancy-related deaths globally and has a
significant impact on women's quality of life. Despite significant therapeutic advances, there …

[HTML][HTML] Regulation of the unfolded protein response during dehydration stress in African clawed frogs, Xenopus laevis

AI Malik, JM Storey, KB Storey - Cell Stress and Chaperones, 2023 - Elsevier
The unfolded protein response (UPR) is a wide-ranging cellular response to accumulation of
malfolded proteins in the endoplasmic reticulum (ER) and acts as a quality control …

LncRNA‐SULT1C2A regulates Foxo4 in congenital scoliosis by targeting rno‐miR‐466c‐5p through PI3K‐ATK signalling

C Chen, H Tan, J Bi, L Li, T Rong, Y Lin… - Journal of Cellular …, 2019 - Wiley Online Library
Congenital scoliosis (CS) is the result of anomalous vertebrae development, but the
pathogenesis of CS remains unclear. Long non‐coding RNAs (lncRNAs) have been …

The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis)

BE Luu, Y Zhang, KB Storey - Cell Stress and Chaperones, 2020 - Springer
Abstract The African clawed frog (Xenopus laevis) naturally tolerates severe dehydration
using biochemical adaptation, one of which is the elevation of antioxidant defenses during …

MicroRNA, mRNA and protein responses to dehydration in skeletal muscle of the African-clawed frog, Xenopus laevis

A Erman, LJ Hawkins, KB Storey - Gene Reports, 2022 - Elsevier
During the dry season in southern Africa, the predominantly aquatic African-clawed frog
(Xenopus laevis) burrows into the wet mud of ponds and marshes. As drying continues frogs …

Insights from a vertebrate model organism on the molecular mechanisms of whole-body dehydration tolerance

BE Luu, LJ Hawkins, KB Storey - Molecular and Cellular Biochemistry, 2021 - Springer
Studies on the molecular mechanisms of dehydration tolerance have been largely limited to
plants and invertebrates. Currently, research in whole body dehydration of complex animals …