Stress is commonly regarded as an important trigger for relapse and a significant factor that
promotes increased motivation to drink in some individuals. However, the relationship …

Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

The comorbidity of depression and addiction has become a serious public health issue, and
the relationship between these two disorders and their potential mechanisms has attracted …

Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …

Individuals frequently differ in their behavioral and cognitive responses to stress. However,
whether motivation is differently affected by acute stress in different individuals remains to be …

Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased
ethanol seeking and consumption, accompanied by activation of the neuroinflammatory …

Both the ostensibly aversive effects of unpredictable episodes of social stress and the
intensely rewarding effects of drugs of abuse activate the mesocorticolimbic dopamine …

Stress is a well-known risk factor for subsequent alcohol abuse, but the neural mechanisms
underlying interactions between stress and alcohol remain largely unknown. Addictive drug …

Mood disorders, including major depressive disorder (MDD), are the most prevalent
psychiatric illnesses, and pose an incredible burden to society, both in terms of disability and …

Our laboratory has previously demonstrated that daily forced swim stress (FSS) prior to
ethanol drinking sessions facilitates enhanced ethanol consumption in mice with a history of …