Integration of drug, protein, and gene delivery systems with regenerative medicine

ER Lorden, HM Levinson, KW Leong - Drug delivery and translational …, 2015 - Springer
Regenerative medicine has the potential to drastically change the field of health care from
reactive to preventative and restorative. Exciting advances in stem cell biology and cellular …

Recent progress in copolymer-mediated siRNA delivery

ZW Wu, CT Chien, CY Liu, JY Yan… - Journal of drug targeting, 2012 - Taylor & Francis
RNAi-mediated gene silencing has great potential for treating various diseases, including
cancer, by delivering a specific short interfering RNA (siRNA) to knock down pathogenic …

Efficient in Vitro siRNA Delivery and Intramuscular Gene Silencing Using PEG-Modified PAMAM Dendrimers

Y Tang, YB Li, B Wang, RY Lin… - Molecular …, 2012 - ACS Publications
Although siRNA techniques have been broadly applied as a tool for gene knockdown,
substantial challenges remain in achieving efficient delivery and in vivo efficacy. In …

Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma

RR Malla, S Gopinath, CS Gondi, K Alapati… - Cancer gene …, 2011 - nature.com
Angiogenesis, which is the process of sprouting of new blood vessels from pre-existing
vessels, is vital for tumor progression. Proteolytic remodeling of extracellular matrix is a key …

Inulin sugar glasses preserve the structural integrity and biological activity of influenza virosomes during freeze-drying and storage

J de Jonge, JP Amorij, WLJ Hinrichs, J Wilschut… - european journal of …, 2007 - Elsevier
Influenza virosomes are reconstituted influenza virus envelopes that may be used as
vaccines or as carrier systems for cellular delivery of therapeutic molecules. Here we …

The clinical and biologic importance of neovascularization and angiogenic signaling pathways in chronic lymphocytic leukemia

TD Shanafelt, NE Kay - Seminars in oncology, 2006 - Elsevier
Angiogenesis has been found to be an important regulator in the growth and metastasis of
solid tumors. More recent studies have also demonstrated the importance of this biologic …

Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles

P Vader, BJ Crielaard, SM Van Dommelen… - Journal of controlled …, 2012 - Elsevier
Angiogenesis is an attractive target for cancer therapy, due to its central position in tumor
growth and development. Vascular Endothelial Growth Factor (VEGF) and its receptors …

Investigation of the therapeutic efficacy of codelivery of psiRNA–vascular endothelial growth factor and pIL-4 into chitosan nanoparticles in the breast tumor model

E Şalva, SO Turan, L Kabasakal, S Alan… - Journal of …, 2014 - Elsevier
Angiogenesis has been known to increase tumor growth and for its metastatic potential in
human tumors. Vascular endothelial growth factor (VEGF) plays an important role in tumor …

Efficient siRNA delivery using PEG-conjugated PAMAM dendrimers targeting vascular endothelial growth factor in a CoCl2-induced neovascularization model in …

L Xu, W Shen, B Wang, X Wang, G Liu… - Current Drug …, 2016 - ingentaconnect.com
Background: Choroidal neovascularization (CNV), also known as subretinal
neovascularization, causes serious damage to the central vision as it happens more …

Lymphangiogenesis and its regulation in human neuroblastoma

J Lagodny, E Jüttner, G Kayser, CM Niemeyer… - Biochemical and …, 2007 - Elsevier
For the first time, we could detect lymph vessels in neuroblastoma (NB) by
immunohistochemistry with the antibody D2_40. Furthermore, we demonstrate expression of …